Clinical Trial Patient Recruitment

$995.00

Understand the key factors that draw patients to clinical trials – and use this information to chart a successful recruiting strategy.  Detailed benchmarks and best practices from more than 80 companies across the life science industries.  Explore in-depth benchmarks focused on these areas:

  • Patient recruitment and retention strategies
  • Specific patient recruitment activities and tools
  • Structure and spending for formal patient recruiting efforts

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Report Details

Publication Date: August 2010
Pages: 209
Chapters: 5
Metrics: 500+
No. of companies: 84
Charts/Graphics: 160+

Top Reasons to Buy this Clinical Trial Patient Recruitment Report

Master Recruiting and Retention: Avoid costly delays and keep trials on track – explore 16 recruitment activities by tracking who performs them and how useful and efficient they are. Break down data by phase to deploy different strategies depending on development stage.

Of course, recruiting patients is only half of the job. Discover inexpensive and simple strategies that make it easier for patients to stay engaged in trials, mitigating the effects of dropout.

Make Studies Attractive to Patients:  Attracting patients requires an in-depth understanding of their needs. Learn both the tangible and emotional reasons why patients participate in trials. Use market research and patient demographics to bolster your advantage and take a more marketing-focused approach.

Deliver Site Support:  Manage site and investigator expectations and strengthen site support through training to help increase patient enrollment.

Ensure adequate resources for patient recruitment:  Our research finds that some companies do not plan ahead for patient recruitment — meaning that it only gets attention when problems arise. Use benchmarks to develop a recruitment process and structure that includes sufficient funding and strategic partnerships with CROs.

You may also be interested in CEIConnect: The Lifesciences Industry’s On-Demand Research Resource as well as our individual clinical development research reports.

Excerpt from Clinical Trial Patient Recruitment

Clinical trial costs are increasing amid a shortage of patients, fewer new drug approvals each year and little to no growth in the number of available clinical investigators. In the wake of safety-related drug recalls, such as those that occurred with Vioxx and Bextra, regulatory agencies are requesting more and more safety data. Sometimes they request completely new trials.

The increased demand for safety data has also sent the demand for patients exponentially higher. Trial managers are in a fierce competition to recruit patients within popular and niche patient populations. Exacerbating this demand for patients is the relatively flat growth in number of clinical investigators and sites; in other words, the capacity to perform clinical trials is not keeping pace with demand. And, if recruiting patients was not challenging enough, retaining them through rigorous mortality and morbidity trials can be even more difficult. Patient dropout rates can climb up as high as 30% in certain therapeutic areas.

Table of Contents

13           Executive Summary

17           Study Methodology

18           Study Definitions

19           Profiled Companies

20           Patient Recruitment: Five Key Findings and Recommendations

27           Supporting Patient Recruitment with Increased Budgets

79           Integrating CRO Outsourcing with Internal Structure

80           Patient Recruitment Structure

84           Using a CRO to Assist with Patient Recruitment

88           Best Practices in CRO Contracting

95           Methods and Activities to Improve Patient Recruitment

97           Site and Patient Demographic Evaluation

107         Site Development

115         Mass Media Marketing

123         External Patient Recruitment Activities

131         Patient Motivators and Patient Retention

132         Patient Motivators

142         Patient Retention

155         Company Profiles

156         Oncology Trials

170         Type 2 Diabetes Trials

174         Obesity Trials

176         Cardiology and Thrombosis Trials

180         CNS/Neurology Trials

186         Mental Health Trials

190         Hematology Trials

192         Infectious Disease Trials

196         Pain Trials

198         Rheumatology Trials

200         Respiratory Trials

202         Medical Technology Trials

204         Consumer Products Trials

206         Other Trials

Charts and Graphics

Executive Summary

20           Figure E.1: Percentage of Participants that Use Patient Retention Strategies by Company Type

23           Figure E.2: Overall Effectiveness Ratings of Patient Motivators

Supporting Patient Recruitment with Increased Budgets

29           Figure 1.1: Percentage of Clinical Trial Budget Dedicated to Patient Recruitment: Phase 1

29           Figure 1.2: Total Phase 1 Trial Budgets: Trial-Level and Site-specific Level

30           Figure 1.3: Dedicated Patient Recruitment Budgets (Trials and Sites): Phase 1

31           Figure 1.4: Dedicated Per Patient Recruitment Budget: Phase 1

32           Figure 1.5: Total Phase 2 Trial Budgets (Sponsor Companies/CROs)

33           Figure 1.6: Percentage of Overall Trial Budget Dedicated to Patient Recruitment (Sponsor Companies/CROs):

Phase 2

34           Figure 1.7: Dedicated Patient Recruitment Budgets (Sponsor Companies/CROs): Phase 2

35           Figure 1.8: Dedicated Per Patient Recruitment Budgets (Sponsor Companies/CROs): Phase 2

36           Figure 1.9: Total Phase 2 Trial Budgets (Sites)

37           Figure 1.10: Percentage of Overall Trial Budget Dedicated to Patient Recruitment (Sites): Phase 2

38           Figure 1.11: Dedicated Patient Recruitment Budgets (Sites): Phase 2

39           Figure 1.12: Dedicated Per Patient Recruitment Budgets (Sites): Phase 2

40           Figure 1.13: Total Phase 3a Trial Budgets (Sponsor Companies/CROs)

41           Figure 1.14: Percentage of Overall Trial Budget Dedicated to Patient Recruitment (Sponsor Companies/CROs):

Phase 3a

42           Figure 1.15: Dedicated Patient Recruitment Budgets (Sponsor Companies/CROs): Phase 3a

43           Figure 1.16: Dedicated Per Patient Recruitment Budgets (Sponsor Companies/CROs): Phase 3a

44           Figure 1.17: Total Phase 3a Trial Budgets (Sites)

45           Figure 1.18: Percentage of Overall Trial Budget Dedicated to Patient Recruitment (Sites): Phase 3a

46           Figure 1.19: Dedicated Patient Recruitment Budgets (Sites): Phase 3a

47           Figure 1.20: Dedicated Per Patient Recruitment Budgets (Sites): Phase 3a

48           Figure 1.21: Total Phase 3b Trial Budgets (Sponsor Companies/CROs)

49           Figure 1.22: Percentage of Overall Trial Budget Dedicated to Patient Recruitment (Sponsor Companies/CROs):

Phase 3b

50           Figure 1.23: Dedicated Patient Recruitment Budgets (Sponsor Companies/CROs): Phase 3b

51           Figure 1.24: Dedicated Per Patient Recruitment Budgets (Sponsor Companies/CROs): Phase 3b

52           Figure 1.25: Total Phase 3b Trial Budgets (Sites)

53           Figure 1.26: Percentage of Overall Trial Budget Dedicated to Patient Recruitment (Sites): Phase 3b

53           Figure 1.27: Dedicated Patient Recruitment Budgets (Sites): Phase 3b

54           Figure 1.28: Dedicated Per Patient Recruitment Budgets (Sites): Phase 3b

55           Figure 1.29: Total Phase 4 Trial Budgets (Sponsor Companies/CROs)

56           Figure 1.30: Percentage of Overall Trial Budget Dedicated to Patient Recruitment (Sponsor Companies/CROs):

Phase 4

57           Figure 1.31: Dedicated Patient Recruitment Budgets (Sponsor Companies/CROs): Phase 4

58           Figure 1.32: Dedicated Per Patient Recruitment Budgets (Sponsor Companies/CROs): Phase 4

59           Figure 1.33: Dedicated Per Patient Recruitment Budgets: Cardiovascular

60           Figure 1.34: Percentage of Overall Trial Budget Dedicated to Patient Recruitment: Cardiovascular

61           Figure 1.35: Dedicated Per Patient Recruitment Budgets: Central Nervous System/Neurology

62           Figure 1.36: Percentage of Overall Trial Budget Dedicated to Patient Recruitment: Central Nervous System/

 Neurology

63           Figure 1.37: Dedicated Per Patient Recruitment Budgets: Diabetes Type 2

64           Figure 1.38: Percentage of Overall Trial Budget Dedicated to Patient Recruitment: Diabetes Type 2

65           Figure 1.39: Budget Dedicated Per Patient for Recruitment and Percent of Total Budget: Hematology

66           Figure 1.40: Dedicated Per Patient Recruitment Budgets: Infectious Disease

67           Figure 1.41: Percentage of Overall Trial Budget Dedicated to Patient Recruitment: Infectious Disease

68           Figure 1.42: Budget Dedicated Per Patient for Recruitment and Percent of Total Budget: Inflammation

69           Figure 1.43: Dedicated Per Patient Recruitment Budgets: Mental Health

70           Figure 1.44: Percentage of Overall Trial Budget Dedicated to Patient Recruitment: Mental Health

71           Figure 1.45: Dedicated Per Patient Recruitment Budgets: Oncology

72           Figure 1.46: Percentage of Overall Trial Budget Dedicated to Patient Recruitment: Oncology

73           Figure 1.47: Dedicated Per Patient Recruitment Budgets: Pain

74           Figure 1.48: Percentage of Overall Trial Budget Dedicated to Patient Recruitment: Pain

75           Figure 1.49: Dedicated Per Patient Recruitment Budgets: Urology

76           Figure 1.50: Percentage of Overall Trial Budget Dedicated to Patient Recruitment: Urology

77           Figure 1.51: Dedicated Per Patient Recruitment Budgets: Medical Device/Diagnostic

77           Figure 1.52: Percentage of Overall Trial Budget Dedicated to Patient Recruitment: Medical Device/Diagnostic

Integrating CRO Outsourcing with Internal Structure

Patient Recruitment Structure

80           Figure 2.1: Percentage of Companies that Maintain a Dedicated Patient Recruitment Group

81           Figure 2.2: Does Any Internal Group Consider Patient Recruitment Within Their Responsibilities?

82           Figure 2.3: Percentage of Companies that Incorporate Patient Recruitment into Trial Protocol   Design by Company Type

Using a CRO to Assist with Patient Recruitment

85           Figure 2.4: Percentage of Participants that Complete All Patient Recruitment In-house or Use CROs by Company Type

86           Figure 2.5: Reasons Companies Contract with CROs for Patient Recruitment Needs

Methods and Activities to Improve Patient Recruitment

Site and Patient Demographic Evaluation

97           Figure 3.1: Percentage of Participants that Rely on Key Stakeholders to Evaluate Sites and Investigators

99           Figure 3.2: Effectiveness Ratings of Evaluating Sites and Investigators by Phase

101         Figure 3.3: Percentage of Participants that Rely on Key Stakeholders to Conduct Patient Demographic/

Population Research

102         Figure 3.4: Effectiveness Ratings of Conducting Patient Demographic/Population Research by Phase

103         Figure 3.5: Percentage of Participants that Rely on Key Stakeholders to Work with Advocacy Groups

104         Figure 3.6: Effectiveness Ratings of Working with Advocacy Groups by Phase

105         Figure 3.7: Percentage of Participants that Rely on Key Stakeholders to Organize Health Fairs and Community Outreach

106         Figure 3.8: Effectiveness Ratings of Organizing Health Fairs and Community Outreach by Phase

Site Development

107         Figure 3.9: Effectiveness Ratings of Recruiting at Point of Care by Phase

108         Figure 3.10: Percentage of Participants that Rely on Key Stakeholders to Train Site Staff/Investigators of Patient Recruitment

109         Figure 3.11: Effectiveness Ratings of Training Sites and Investigators on Patient Recruitment by Phase

110         Figure 3.12: Percentage of Participants that Rely on Key Stakeholders to Develop Recruitment Kits

112         Figure 3.13: Effectiveness Ratings of Developing Recruitment Kits by Phase

113         Figure 3.14: Percentage of Participants that Rely on Key Stakeholders to Manage Online Patient Resources

114         Figure 3.15: Effectiveness Ratings of Managing Online Patient Resources by Phase

Mass Media Marketing

117         Figure 3.16: Percentage of Participants that Rely on Key Stakeholders to Manage Radio Marketing

117         Figure 3.17: Percentage of Participants that Rely on Key Stakeholders to Manage Newspaper/Print Marketing

118         Figure 3.18: Percentage of Participants that Rely on Key Stakeholders to Manage Television Marketing

118         Figure 3.19: Percentage of Participants that Rely on Key Stakeholders to Manage Web-Based Marketing

120         Figure 3.20: Effectiveness Ratings of Managing Radio Marketing by Phase

120         Figure 3.21: Effectiveness Ratings of Managing Newspaper/Print Marketing by Phase

121         Figure 3.22: Effectiveness Ratings of Managing Television Marketing by Phase

121         Figure 3.23: Effectiveness Ratings of Managing Web-Based Marketing by Phase

External Patient Recruitment Activities

123         Figure 3.24: Percentage of Participants that Rely on Key Stakeholders to Utilize Medical Science Liaisons

124         Figure 3.25: Effectiveness of Utilizing Medical Science Liaisons by Phase

125         Figure 3.26: Percentage of Participants that Rely on Key Stakeholders to Manage a Call Center

126         Figure 3.27: Effectiveness Ratings of Managing a Call Center by Phase

127         Figure 3.28: Percentage of Participants that Rely on Key Stakeholders to Reach Out to Other Physicians for Referrals

128         Figure 3.29: Effectiveness Ratings of Reaching Out to Other Physicians for Referrals by Phase

129         Figure 3.30: Percentage of Participants that Rely on Key Stakeholders to Contact Patient Referrals

129         Figure 3.31: Effectiveness Ratings of Contacting Patient Referrals by Phase

Patient Motivators and Patient Retention

Patient Motivators

133         Figure 4.1: Overall Effectiveness Ratings of Patient Motivators

134         Figure 4.2: Effectiveness Ratings of Patient Motivators by Phase: Prospect of Improved Treatment

135         Figure 4.3: Effectiveness Ratings of Patient Motivators by Phase: Convenience of Sites

136         Figure 4.4: Effectiveness Ratings of Patient Motivators by Phase: Prospect of Free Medication/Treatment

137         Figure 4.5: Effectiveness Ratings of Patient Motivators by Phase: Number/Frequency of Visits

138         Figure 4.6: Effectiveness Ratings of Patient Motivators by Phase: Short Trial Duration

139         Figure 4.7: Effectiveness Ratings of Patient Motivators by Phase: Transportation Compensation

140         Figure 4.8: Effectiveness Ratings of Patient Motivators by Phase: Monetary Compensation

141         Figure 4.9: Effectiveness Ratings of Patient Motivators by Phase: Non-Monetary Incentives

Patient Retention

143         Figure 4.10: Percentage of Participants that Use Patient Retention Strategies by Company Type

144         Figure 4.11: Percentage of Participants Using Patient Retention Strategies by Phase: Visit Reminders by Phone

145         Figure 4.12: Percentage of Participants Using Patient Retention Strategies by Phase: Visit Reminders by Mail

146         Figure 4.13: Percentage of Participants Using Patient Retention Strategies by Phase: Visit Reminders by Email

146         Figure 4.14: Percentage of Participants Using Patient Retention Strategies by Phase: Visit Reminders by Text Message

147         Figure 4.15: Percentage of Participants Using Patient Retention Strategies by Phase: Print/Paper Patient Support Materials

148         Figure 4.16: Percentage of Participants Using Patient Retention Strategies by Phase: Online Patient Support Materials

149         Figure 4.17: Percentage of Participants Using Patient Retention Strategies by Phase: Treatment Follow-up by Phone

150         Figure 4.18: Percentage of Participants Using Patient Retention Strategies by Phase: Treatment Follow-up by Web/Email

151         Figure 4.19: Percentage of Participants Using Patient Retention Strategies by Phase: Transportation Assistance

152         Figure 4.20: Percentage of Participants Using Patient Retention Strategies by Phase: Visiting Patients

153         Figure 4.21: Percentage of Participants Using Patient Retention Strategies by Phase: Caregiver Support

Company Profiles

Oncology Trials

156         Figure 5.1: Patient Recruitment Profile For Company 8

157         Figure 5.2: Patient Recruitment Tactics For Company 8

158         Figure 5.3: Patient Recruitment Profile For Company 67

159         Figure 5.4: Patient Recruitment Tactics For Company 67

160         Figure 5.5: Patient Recruitment Profile For Company 74

161         Figure 5.6: Patient Recruitment Tactics For Company 74

162         Figure 5.7: Patient Recruitment Profile For Company 76

163         Figure 5.8: Patient Recruitment Tactics For Company 76

164         Figure 5.9: Patient Recruitment Profile For Company 79

165         Figure 5.10: Patient Recruitment Tactics For Company 79

166         Figure 5.11: Patient Recruitment Profile For Company 81

167         Figure 5.12: Patient Recruitment Tactics For Company 81

168         Figure 5.13: Patient Recruitment Profile For Company 83

169         Figure 5.14: Patient Recruitment Tactics For Company 83

Type 2 Diabetes Trials

170         Figure 5.15: Patient Recruitment Profile For Company 16

171         Figure 5.16: Patient Recruitment Tactics For Company 16

172         Figure 5.17: Patient Recruitment Profile For Company 27

173         Figure 5.18: Patient Recruitment Tactics For Company 27

Obesity Trials

174         Figure 5.19: Patient Recruitment Profile For Company 82

175         Figure 5.20: Patient Recruitment Tactics For Company 82

Cardiology and Thrombosis Trials

176         Figure 5.21: Patient Recruitment Profile For Company 42

177         Figure 5.22: Patient Recruitment Tactics For Company 42

178         Figure 5.23: Patient Recruitment Profile For Company 59

179         Figure 5.24: Patient Recruitment Tactics For Company 59

CNS/Neurology Trials

180         Figure 5.25: Patient Recruitment Profile For Company 41

181         Figure 5.26: Patient Recruitment Tactics For Company 41

182         Figure 5.27: Patient Recruitment Profile For Company 58

183         Figure 5.28: Patient Recruitment Tactics For Company 58

184         Figure 5.29: Patient Recruitment Profile For Company 61

185         Figure 5.30: Patient Recruitment Tactics For Company 61

Mental Health Trials

186         Figure 5.31: Patient Recruitment Profile For Company 50

187         Figure 5.32: Patient Recruitment Tactics For Company 50

188         Figure 5.33: Patient Recruitment Profile For Company 52

189         Figure 5.34: Patient Recruitment Tactics For Company 52

Hematology Trials

190         Figure 5.35: Patient Recruitment Profile For Company 45

191         Figure 5.36: Patient Recruitment Tactics For Company 45

Infectious Disease Trials

192         Figure 5.37: Patient Recruitment Profile For Company 56

193         Figure 5.38: Patient Recruitment Tactics For Company 56

194         Figure 5.39: Patient Recruitment Profile For Company 69

19           5 Figure 5.40: Patient Recruitment Tactics For Company 69

Pain Trials

196         Figure 5.41: Patient Recruitment Profile For Company 55

197         Figure 5.42: Patient Recruitment Tactics For Company 55

Rheumatology Trials

198         Figure 5.43: Patient Recruitment Profile For Company 12

199         Figure 5.44: Patient Recruitment Tactics For Company 12

Respiratory Trials

200         Figure 5.45: Patient Recruitment Profile For Company 62

201         Figure 5.46: Patient Recruitment Tactics For Company 62

Medical Technology Trials

202         Figure 5.47: Patient Recruitment Profile For Company 31

203         Figure 5.48: Patient Recruitment Tactics For Company 31

Consumer Products Trials

204         Figure 5.49: Patient Recruitment Profile For Company 78

205         Figure 5.50: Patient Recruitment Tactics For Company 78

Other Trials

206         Figure 5.51: Patient Recruitment Profile For Company 4

207         Figure 5.52: Patient Recruitment Tactics For Company 4

208         Figure 5.53: Patient Recruitment Profile For Company 70

209         Figure 5.54: Patient Recruitment Tactics For Company 70